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Vaccine Excipient & Media Summary, Part 2

 

Excipients Included in U.S. Vaccines, by Vaccine

 

Includes vaccine ingredients (e.g., adjuvants and preservatives) as well as substances used during the manufacturing process,

including vaccine-production media, that are removed from the final product and present only in trace quantities. In addition to the substances listed, most vaccines contain Sodium Chloride (table salt).

 

 

Vaccine

Contains

 

Anthrax (BioThrax)

Aluminum Hydroxide, Amino Acids, Benzethonium Chloride, Formaldehyde or Formalin, Inorganic Salts, and Sugars, Vitamins

 

BCG (Tice)

Asparagine, Citric Acid, Lactose, Glycerin, Iron Ammonium Citrate, Magnesium

Sulfate, Potassium Phosphate

 

 

DTaP (Daptacel)

Aluminum Phosphate, Ammonium Sulfate, Casamino Acid,

Dimethyl-beta-cyclodextrin, Formaldehyde or Formalin, Glutaraldehyde,

2-Phenoxyethanol

 

DTaP (Infanrix)

Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldehyde, 2-Phenoxyethanol, Polysorbate 80

 

 

DTaP (Tripedia)

Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sodium Phosphate, Thimerosal*

 

DTaP/Hib (TriHIBit)

Aluminum Potassium Sulfate, Ammonium Sulfate, Bovine Extract, Formaldehyde or Formalin, Gelatin, Polysorbate 80, Sucrose, Thimerosal*

 

 

DTaP-IPV (Kinrix)

Aluminum Hydroxide, Bovine Extract, Formaldehyde, Lactalbumin Hydrolysate, Monkey Kidney Tissue, Neomycin Sulfate, Polymyxin B, Polysorbate 80

 

 

DTaP-HepB-IPV (Pediarix)

Aluminum Hydroxide, Aluminum Phosphate, Bovine Protein, Lactalbumin Hydrolysate, Formaldehyde or Formalin, Glutaraldehyde, Monkey Kidney Tissue, Neomycin, 2-Phenoxyethanol, Polymyxin B, Polysorbate 80, Yeast Protein

 

 

DTaP-IPV/Hib (Pentacel)

Aluminum Phosphate, Bovine Serum Albumin, Formaldehyde, Glutaraldehyde, MRC-5 DNA and Cellular Protein, Neomycin, Polymyxin B Sulfate, Polysorbate

80, 2-Phenoxyethanol,

 

DT (Sanofi)

Aluminum Potassium Sulfate, Bovine Extract, Formaldehyde or Formalin, Thimerosal (multi-dose) or Thimerosal* (single-dose)

DT (Massachusetts)

Aluminum Hydroxide, Formaldehyde or Formalin

Hib (ACTHib)

Ammonium Sulfate, Formaldehyde or Formalin, Sucrose

Hib (Hiberix)

Formaldehyde or Formalin, Lactose

Hib (PedvaxHib)

Aluminum Hydroxyphosphate Sulfate

 

Hib/Hep B (Comvax)

Amino Acids, Aluminum Hydroxyphosphate Sulfate, Dextrose, Formaldehyde or

Formalin, Mineral Salts, Sodium Borate, Soy Peptone, Yeast Protein

 

 

Hep A (Havrix)

Aluminum Hydroxide, Amino Acids, Formaldehyde or Formalin, MRC-5

Cellular Protein, Neomycin Sulfate, 2-Phenoxyethanol, Phosphate Buffers,

Polysorbate

 

Hep A (Vaqta)

Aluminum Hydroxyphosphate Sulfate, Bovine Albumin or Serum, DNA, Formaldehyde or Formalin, MRC-5 Cellular Protein, Sodium Borate

Hep B (Engerix-B)

Aluminum Hydroxide, Phosphate Buffers, Thimerosal*, Yeast Protein

  

 

Vaccine

Contains

 

 

Hep B (Recombivax)

Aluminum Hydroxyphosphate Sulfate, Amino Acids, Dextrose, Formaldehyde or Formalin, Mineral Salts, Potassium Aluminum Sulfate, Soy Peptone, Yeast Protein

 

 

HepA/HepB (Twinrix)

Aluminum Hydroxide, Aluminum Phosphate, Amino Acids, Dextrose, Formaldehyde or Formalin, Inorganic Salts, MRC-5 Cellular Protein, Neomycin Sulfate, 2-Phenoxyethanol, Phosphate Buffers, Polysorbate 20, Thimerosal*, Vitamins, Yeast Protein

 

Human Papillomavirus (HPV)Cervarix)

3-O-desacyl-4’-monophosphoryl lipid A (MPL), Aluminum Hydroxide, Amino Acids, Insect Cell Protein, Mineral Salts, Sodium Dihydrogen Phosphate Dihydrate, Vitamins

 

Human Papillomavirus (HPV) (Gardasil)

Amino Acids, Amorphous Aluminum Hydroxyphosphate Sulfate, Carbohydrates, L-histidine, Mineral Salts, Polysorbate 80, Sodium Borate, Vitamins

 

 

Influenza (Afluria)

Beta-Propiolactone, Calcium Chloride, Neomycin, Ovalbumin, Polymyxin B, Potassium Chloride, Potassium Phosphate, Sodium Phosphate, Sodium Taurodeoxychoalate

 

Influenza (Agriflu)

Cetyltrimethylammonium Bromide (CTAB), Egg Protein, Formaldehyde or

Formalin, Kanamycin, Neomycin Sulfate, Polysorbate 80

 

 

Influenza (Fluarix)

Egg Albumin (Ovalbumin), Egg Protein, Formaldehyde or Formalin, Gentamicin, Hydrocortisone, Octoxynol-10, α-Tocopheryl Hydrogen Succinate, Polysorbate 80, Sodium Deoxycholate, Sodium Phosphate, Thimerosal*

 

Influenza (Flulaval)

Egg Albumin (Ovalbumin), Egg Protein, Formaldehyde or Formalin, Sodium

Deoxycholate, Phosphate Buffers, Thimerosal

 

 

Influenza (Fluvirin)

Beta-Propiolactone , Egg Protein, Neomycin, Polymyxin B, Polyoxyethylene

9-10 Nonyl Phenol (Triton N-101, Octoxynol 9), Thimerosal (multidose containers), Thimerosal* (single-dose syringes)

 

Influenza (Fluzone)

Egg Protein, Formaldehyde or Formalin, Gelatin, Octoxinol-9 (Triton X-100), Thimerosal (multidose containers)

 

Influenza (FluMist)

Chick Kidney Cells, Egg Protein, Gentamicin Sulfate, Monosodium Glutamate, Sucrose Phosphate Glutamate Buffer

 

IPV (Ipol)

Calf Serum Protein, Formaldehyde or Formalin, Monkey Kidney Tissue, Neomycin, 2-Phenoxyethanol, Polymyxin B, Streptomycin,

Japanese Encephalitis

(JE-Vax)

Formaldehyde or Formalin, Gelatin, Mouse Serum Protein, Polysorbate 80, Thimerosal

 

Japanese Encephalitis (Ixiaro)

Aluminum Hydroxide, Bovine Serum Albumin, Formaldehyde, Protamine

Sulfate, Sodium Metabisulphite

Meningococcal (Menactra)

Formaldehyde or Formalin, Phosphate Buffers

Meningococcal (Menomune)

Lactose, Thimerosal (10-dose vials only)

Meningococcal (Menveo)

Amino Acid, Formaldehyde or Formalin, Yeast

 

 

MMR (MMR-II)

Amino Acid, Bovine Albumin or Serum, Chick Embryo Fibroblasts, Human Serum Albumin, Gelatin, Glutamate, Neomycin, Phosphate Buffers, Sorbitol, Sucrose, Vitamins


 

 

Vaccine

Contains

 

 

MMRV (ProQuad)

Bovine Albumin or Serum, Gelatin, Human Serum Albumin, Monosodium

L-glutamate, MRC-5 Cellular Protein, Neomycin, Sodium Phosphate Dibasic, Sodium Bicarbonate, Sorbitol, Sucrose, Potassium Phosphate Monobasic, Potassium Chloride, Potassium Phosphate Dibasic

Pneumococcal (Pneumovax)

Bovine Protein, Phenol

Pneumococcal (Prevnar)

Aluminum Phosphate, Amino Acid, Soy Peptone, Yeast Extract

 

Pneumococcal (Prevnar 13)

Aluminum Phosphate, Amino Acid, Polysorbate 80, Soy Peptone, Succinate

Buffer, Yeast Extract

 

Rabies (Imovax)

Human Serum Albumin, Beta-Propiolactone, MRC-5 Cellular Protein, Neomycin, Phenol Red (Phenolsulfonphthalein), Vitamins

 

 

Rabies (RabAvert)

Amphotericin B, Beta-Propiolactone, Bovine Albumin or Serum, Chicken

Protein, Chlortetracycline, Egg Albumin (Ovalbumin),

Ethylenediamine-Tetraacetic Acid Sodium (EDTA), Neomycin, Potassium

Glutamate

 

Rotavirus (RotaTeq)

Cell Culture Media, Fetal Bovine Serum, Sodium Citrate, Sodium Phosphate

Monobasic Monohydrate, Sodium Hydroxide Sucrose, Polysorbate 80

 

 

Rotavirus (Rotarix)

Amino Acids, Calcium Carbonate, Calcium Chloride, D-glucose, Dextran, Ferric (III) Nitrate, L-cystine, L-tyrosine, Magnesium Sulfate, Phenol Red, Potassium Chloride, Sodium Hydrogenocarbonate, Sodium Phosphate, Sodium

L-glutamine, Sodium Pyruvate, Sorbitol, Sucrose, Vitamins, Xanthan

 

Td (Decavac)

Aluminum Potassium Sulfate, Bovine Extract, Formaldehyde or Formalin,

2-Phenoxyethanol, Peptone, Thimerosal*

 

Td (Massachusetts)

Aluminum Hydroxide, Aluminum Phosphate, Formaldehyde or Formalin, Thimerosal (some multidose containers)

 

Tdap (Adacel)

Aluminum Phosphate, Formaldehyde or Formalin, Glutaraldehyde,

2-Phenoxyethanol

 

Tdap (Boostrix)

Aluminum Hydroxide, Bovine Extract, Formaldehyde or Formalin, Glutaraldehyde, Polysorbate 80

Typhoid (inactivated Typhim

Vi)

Disodium Phosphate, Monosodium Phosphate, Phenol, Polydimethylsilozone, Hexadecyltrimethylammonium Bromide

 

Typhoid (oral Ty21a)

Amino Acids, Ascorbic Acid, Bovine Protein, Casein, Dextrose, Galactose, Gelatin, Lactose, Magnesium Stearate, Sucrose, Yeast Extract

 

Vaccinia (ACAM2000)

Glycerin, Human Serum Albumin, Mannitol, Monkey Kidney Cells, Neomycin, Phenol, Polymyxin B

 

 

Varicella (Varivax)

Bovine Albumin or Serum, Ethylenediamine-Tetraacetic Acid Sodium (EDTA), Gelatin, Monosodium L-Glutamate, MRC-5 DNA and Cellular Protein, Neomycin, Potassium Chloride, Potassium Phosphate Monobasic, Sodium Phosphate Monobasic, Sucrose

Yellow Fever (YF-Vax)

Egg Protein, Gelatin, Sorbitol

 

 

Zoster (Zostavax)

Bovine Calf Serum, Hydrolyzed Porcine Gelatin, Monosodium L-glutamate, MRC-5 DNA and Cellular Protein, Neomycin, Potassium Phosphate Monobasic, Potassium Chloride, Sodium Phosphate Dibasic, Sucrose


*Where thimerosal” is marked with an asterisk (*) it indicates that the product should be considered equivalent to thimerosal-free products. This vaccine may contain trace amounts (3 mcg) of mercury left after post-production thimerosal removal, but these amounts have no biological effect. JAMA 1999;282(18) and JAMA 2000;283(16)

 

Adapted from Grabenstein JD. ImmunoFacts: Vaccines & Immunologic Drugs. St. Louis, MO: Wolters Kluwer

Health Inc.; 2009 and individual products package inserts.

 

All reasonable efforts have been made to ensure the accuracy of this information, but manufacturers may change product contents before that information is reflected here.

 

This document can be found on the CDC website at:

http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf

 

 To obtain more information on vaccination safety and to schedule your appointment  please call our office at (800)669-0358 and discover preventive methods to health and healing 

  

 

 

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